If you have a family history of Type 1 Diabetes (T1D), have
the immediate family (including children), screened for the disease. This is to
identify anyone who may have Latent autoimmune diabetes of adults (LADA) that
will rear its ugly head years later.
A study by nip et al.
demonstrated that all children initially tested positive for diabetes-associated
autoantibodies (GADA and IA-2A) progressed to clinical Type 1 Diabetes over a
26-year follow-up.
These auto antibodies can be used efficiently for the
prediction of T1D in first-degree relatives of affected patients with high
probability of developing the disease over the subsequent 27 years according to
European Union studies. Therefore, screening people with a family history of
T1D can serve as prediction of future need for insulin treatment in adult-onset
diabetes.
In USA and Europe, the frequency of autoantibodies against
IA-2 ranges between 60 to 80% in newly diagnosed T1D children. This figure
dropped to around 45% in those diagnosed after the age of 20.
The presence of GADA appears to increase with age.
Therefore, the latter can be used to identify autoimmune diabetes in adults
masquerading as type 2 diabetes. Moreover, the presence of GADA can predict progression to Type 1 Diabetes
for adults who do not have any signs of
the disease (LADA).
Related article: Type 2
Diabetes & Insulin Resistance
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